Dr. Ryan M. Naylor is a fellowship-trained cerebrovascular neurosurgeon specializing in the open microsurgical and endovascular management of complex neurovascular disorders. His expertise includes the treatment of intracranial aneurysms, arteriovenous malformations and fistulas, cavernous malformations, intracranial and extracranial steno-occlusive disease, ischemic and hemorrhagic stroke, chronic subdural hematoma, idiopathic intracranial hypertension, and hydrocephalus.
He also has advanced training in skull base neurosurgery and treats patients with extra-axial and intra-axial brain tumors as well as cranial neuralgias (including trigeminal, glossopharyngeal, and hemifacial spasm).
Additionally, Dr. Naylor has particular expertise in the diagnosis and treatment of spontaneous intracranial hypotension, employing both endovascular embolization of CSF–venous fistulas and microsurgical repair of spontaneous spinal CSF leaks.
Dr. Naylor earned his B.S. in Biological Sciences and Chemistry from the University of California, Irvine, followed by his M.D. and Ph.D. degrees from the Mayo Clinic Alix School of Medicine and Mayo Clinic Graduate School of Biomedical Sciences, respectively. He completed his neurosurgery residency at the Mayo Clinic, where he also completed enfolded fellowships in endovascular neurosurgery and skull base oncology.
Dr. Naylor has authored more than 60 peer-reviewed publications. His basic science research focuses on elucidating the biological mechanisms underlying brain arteriovenous malformations and developing novel therapeutic strategies for their treatment. He is also interested in outcomes-based clinical neurosurgery research and operative video scholarship.
Mayo Clinic
Rochester, MN
- Skull Base Neurosurgery
2025
Mayo Clinic
Rochester, MN
- Neurosurgery Residency
2025
Mayo Clinic
Rochester, MN
- Endovascular Neurosurgery
2023
Mayo Clinic
Rochester, MN
MD - Medicine
2018
Mayo Clinic
Rochester, MN
PhD - Cell and Molecular Biology
2016
Dual MAPK/VEGF inhibition for KRAS-mutated brain arteriovenous malformations.
Dual MAPK/VEGF inhibition for KRAS-mutated brain arteriovenous malformations. J Neurosurg. 2026 Feb 01; 144(2):452-461.
PMID: 41172372
Microsurgical obliteration of a superior petrosal dural arteriovenous fistula presenting with a symptomatic brainstem cavernous malformation.
Microsurgical obliteration of a superior petrosal dural arteriovenous fistula presenting with a symptomatic brainstem cavernous malformation. Neurosurg Focus Video. 2025 Oct; 13(2):V2.
PMID: 41113739
Impact of duration of dual anti-platelet therapy on risk of complications after stent-assisted coiling of unruptured aneurysms.
Impact of duration of dual anti-platelet therapy on risk of complications after stent-assisted coiling of unruptured aneurysms. J Neurointerv Surg. 2025 Aug 13; 17(9):956-960.
PMID: 39137967
Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video.
Resection of a Cerebellopontine Angle Ependymoma Using a Far Lateral Approach: 2-Dimensional Operative Video. Oper Neurosurg. 2026 Feb 01; 30(2):330.
PMID: 40298388
Advances in sporadic brain arteriovenous malformations: Novel genetic insights, innovative animal models and emerging therapeutic approaches.
Advances in sporadic brain arteriovenous malformations: Novel genetic insights, innovative animal models and emerging therapeutic approaches. J Cereb Blood Flow Metab. 2025 May; 45(5):793-799.
PMID: 39948029
Triple Aspiration versus Conventional Aspiration Techniques: A Randomized In Vitro Evaluation.
Triple Aspiration versus Conventional Aspiration Techniques: A Randomized In Vitro Evaluation. AJNR Am J Neuroradiol. 2025 Jan 08; 46(1):90-95.
PMID: 38991770
Traumatic retroclival hematoma resulting in abducens nerve palsy: illustrative case.
Traumatic retroclival hematoma resulting in abducens nerve palsy: illustrative case. J Neurosurg Case Lessons. 2025 Jan 06; 9(1).
PMID: 39761556
Microsurgical Resection of a Vermian Hemangioblastoma Using the Occipital Interhemispheric Transtentorial Approach: 2-Dimensional Operative Video.
Microsurgical Resection of a Vermian Hemangioblastoma Using the Occipital Interhemispheric Transtentorial Approach: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2024 Nov 07; 29(2):314.
PMID: 39508586
Microsurgical Resection of a Vermian Hemangioblastoma Using the Occipital Interhemispheric Transtentorial Approach: 2-Dimensional Operative Video.
Microsurgical Resection of a Vermian Hemangioblastoma Using the Occipital Interhemispheric Transtentorial Approach: 2-Dimensional Operative Video. Oper Neurosurg. 2024 Nov 07; 29(2):314.
PMID: 39508586
Ventral Thoracic Cerebrospinal Fluid Leak Repair in Spontaneous Intracranial Hypotension Complicated by Superficial Siderosis: 2-Dimensional Operative Video.
Ventral Thoracic Cerebrospinal Fluid Leak Repair in Spontaneous Intracranial Hypotension Complicated by Superficial Siderosis: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2025 Jun 01; 28(6):893-894.
PMID: 39352142
The Aneurysm and AVM Foundation Cerebrovascular Research Grant Awardee (award deferred)
Mayo Clinic
2023 - 2024
NREF Research Fellowship Grant & Young Clinician Investigator Award Recipient
Mayo Clinic
2023 - 2024
Resident Teacher of the Year Award
Mayo Clinic
2023 - 2024
David G. Piepgras Award for Excellence in Neurosurgery
Mayo Clinic
2023 - 2024
Thomas M. and Edna T. Gattle Award for Neurosurgery Research
Mayo Clinic
2017 - 2018
National Cancer Institute Ruth L. Kirschstein National Research Service F30 Award
Mayo Clinic
2014 - 2018
Luckman MD-PhD Scholarship Award
Mayo Clinic
2010 - 2014