Peleg Horowitz is a neurosurgeon with expertise in brain and skull base tumors as well as endoscopic and open surgical approaches to the skull base. This includes incorporation of advanced stereotactic and 3-D surgical planning for operative treatment and radiosurgery of both benign and malignant brain and skull base tumors, including gliomas, meningiomas, schwannomas, and pituitary tumors. Along with Endocrinologist Susan Sam, MD, he leads the neurosurgical efforts of the University of Chicago Pituitary and Neuroendocrine Disorders program.
In addition to his interest in neurosurgical oncology, he also practices general neurosurgery, treating patients with a wide range of diseases, including head trauma in adults and children, and served as the Interim Director of Neurosurgical Trauma for the opening of the University of Chicago Level One Trauma Center.
His past scholarly work has focused on the pathogenesis and management of nervous system tumors, and his research has identified several novel genes that drive the formation of meningiomas and pediatric gliomas. His research on tumor genetics has been published in Nature Genetics and Proceedings of the National Academy of Sciences of the United States of America, and has been funded by the Brain Science Foundation and the US Department of Defense Neurofibromatosis Research Program.
Horowitz received his bachelor’s degree in biology and a PhD in neuroscience from Northwestern University, as well as an MD from the Feinberg School of Medicine at Northwestern University. He completed his internship and residency at Brigham and Women’s Hospital/Children’s Hospital Boston, and a skull base surgical neurooncology fellowship at the University of Texas MD Anderson Cancer Center.
MD Anderson Cancer Center
Houston, TX
- Skull Base Neurosurgical Oncology Fellowship
2016
Brigham and Women's Hospital / Boston Children's Hospital / Harvard Medical School
Boston, MA
- Neurosurgical Residency
2015
Northwestern University School of Medicine
Chicago, IL
MD / PhD - Neuroscience, Medicine
2008
Northwestern University
Evanston, IL
BA - Biology (Neuroscience)
2000
Clinical Reasoning: A 41-Year-Old Man Presenting With Right Foot Tingling.
Clinical Reasoning: A 41-Year-Old Man Presenting With Right Foot Tingling. Neurology. 2026 Apr 28; 106(8):e214781.
PMID: 41886714
AI-Aided Triage for GSWH: Validating an Interpretable HCT-Based Mortality Model.
AI-Aided Triage for GSWH: Validating an Interpretable HCT-Based Mortality Model. J Neurotrauma. 2026 Sep; 43(17-18):1433-1442.
PMID: 41805068
Brain Imaging Features in Patients with Gunshot Wounds to the Head.
Brain Imaging Features in Patients with Gunshot Wounds to the Head. J Neurotrauma. 2025 Apr; 42(7-8):689-699.
PMID: 39899350
"Just Got Diagnosed; What Worked for You?": A Mixed-Methods Analysis of Treatment Experiences in the Prolactinoma Subreddit.
"Just Got Diagnosed; What Worked for You?": A Mixed-Methods Analysis of Treatment Experiences in the Prolactinoma Subreddit. J Neurol Surg B Skull Base. 2025 Aug; 86(4):480-487.
PMID: 40620626
Sentiment Analysis of Transsphenoidal Surgery in the Cushing's Subreddit.
Sentiment Analysis of Transsphenoidal Surgery in the Cushing's Subreddit. J Neurol Surg B Skull Base. 2025 Aug; 86(4):488-494.
PMID: 40620631
Comparative Analysis of Clinical Severity and Outcomes in Penetrating Versus Blunt Traumatic Brain Injury Propensity Matched Cohorts.
Comparative Analysis of Clinical Severity and Outcomes in Penetrating Versus Blunt Traumatic Brain Injury Propensity Matched Cohorts. Neurotrauma Rep. 2024; 5(1):348-358.
PMID: 38595793
The Time Burden of Office Visits in Contemporary Pituitary Care, 2016 to 2019.
The Time Burden of Office Visits in Contemporary Pituitary Care, 2016 to 2019. Am J Rhinol Allergy. 2024 Jul; 38(4):203-210.
PMID: 38544422
Comparative Effectiveness of Early Neurosurgical Intervention in Civilian Penetrating Brain Injury Management.
Comparative Effectiveness of Early Neurosurgical Intervention in Civilian Penetrating Brain Injury Management. Neurosurgery. 2024 Mar 01; 94(3):470-477.
PMID: 37847039
Determining the association of insurance coverage and survival outcomes in patients with olfactory neuroblastoma utilizing machine learning.
Determining the association of insurance coverage and survival outcomes in patients with olfactory neuroblastoma utilizing machine learning. Int Forum Allergy Rhinol. 2023 11; 13(11):2082-2085.
PMID: 37132277
Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation.
Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation. J Stroke Cerebrovasc Dis. 2023 Jul; 32(7):107167.
PMID: 37146402