Thompson lab

Research Projects

The Thompson Lab focuses on 

1. Elucidating the cellular molecular mechanisms of the leptomeningeal dissemination of pediatric brain tumors such as medulloblastoma and ependymoma

2. Identifying novel therapeutic agents to treat leptomeningeal metastases

3. Unraveling the immunogenic mechanism of oncolytic viral therapy for the treatment of pediatric brain and leptomeningeal tumors

Publications: 

• Eric M. Thompson, Thomas Hielscher, Eric Bouffet, et al. ­Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: A Retrospective Integrated Clinical and Molecular Analysis. Lancet Oncology. 2016; 17(4):484-95.
• Eric M. Thompson, Stephen T. Keir, Talaignair Venkatraman, Christopher Lascola, Kristen W. Yeom, Andrew Nixon, Yingmiao Liu, Daniel Picard, Marc Remke, Darell D. Bigner, Vijay Ramaswamy, Michael D. Taylor. The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival. Neuro-Oncology. 2017; 19(9):1217-27.
• Maria C Vladoiu, Ibrahim El-Hamamy, Laura K Donovan et al…. Eric M. Thompson, Claudia L Kleinman, Alexandra L. Joyner, Nada Jabado, Lincoln Stein, Michael D. Taylor. Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs. Nature. 2019;572(7767):67-73.
• Liam D. Hendrikse, Parthiv Haldipur, Oliver Saulneir…Eric M. Thompson…Hiromichi Suzuki, Kathleen J. Millen, Michael D. Taylor. Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 222;609(7929):1021-1028.
• Eric M. Thompson, Michael Brown, Elena Dobrikova, Vijay Ramaswamy, Michael Taylor, Roger McLendon, Jennifer Sanks, Vidya Chandramohan, Darell Bigner, Matthias Gromeier. Poliovirus receptor (CD155) expression in pediatric brain tumors mediates oncolysis of medulloblastoma and pleomorphic xanthoastrocytoma. Journal of Neuropathology and Experimental Neurology. 2018. 77(8):696-702.
• Sean Li, Roger McLendon, Eric Sankey, Reb Kornahrens, Anne-Marie Lyne, Florence M.G. Cavalli, Zachary McKay, James E. Herndon II, Marc Remke, Daniel Picard, Matthias Gromeier, Michael Brown, Eric M. Thompson. CD155 is a Putative Therapeutic Target in Medulloblastoma. Clinical and Translational Oncology. 2022. Epub Oct 2022.
• Eric M. Thompson, Daniel Landi, Michael C. Brown, Henry S. Friedman, Roger McLendon, James E. Herndon, II, Evan Buckley, Dani P. Bolognesi, Eric Lipp, Kristin Schroeder, Oren J. Becher, Allan H. Friedman, Zachary McKay, Ashley Walter, Stevie Threatt, Denise Jaggers, Annick Desjardins, Matthias Gromeier, Darell D. Bigner, David M. Ashley. Phase Ib Trial of Recombinant Polio:rhinovirus Immunotherapy for Recurrent Pediatric High Grade Glioma. The Lancet Child & Adolescent Health. Accepted for publication. 2023.
• Stephen Harward, S. Harrison Farber, Michael Malinzak, Oren Becher, Eric M. Thompson. T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity. Child’s Nervous System. 2018; 34(3):449-455.
• Vadim Tsvankin, Rintaro Hashizume, Hiroaki Katagi, Christopher Lascola,  Talaignair N. Venkatraman, Daniel Picard, Brainard Burrus, Oren J. Becher, Eric M. Thompson. ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. Neurosurgery. 2020; 86(5):742-751.
• Eric M. Thompson, Daniel D Landi, David Ashley, Stephen T. Keir, Darrel D. Bigner. Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status. Journal of Neuro-Oncology. 2018; 140(2):261-268.

Please see the complete list of his publications here!